B-Raf inhibitor
Modify Date: 2025-08-25 18:33:19
B-Raf inhibitor structure
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Common Name | B-Raf inhibitor | ||
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| CAS Number | 1315330-11-0 | Molecular Weight | 552.59100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31F3N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of B-Raf inhibitorTAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively. |
| Name | N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide |
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| Synonym | More Synonyms |
| Description | TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively. |
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| Related Catalog | |
| Target |
TAK1:41.1 nM (IC50) MAP4K2:18.2 nM (IC50) |
| In Vivo | TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t1/2=2.94 h for mice (1 mg/kg, iv))[1]. |
| References |
| Molecular Formula | C29H31F3N6O2 |
|---|---|
| Molecular Weight | 552.59100 |
| Exact Mass | 552.24600 |
| PSA | 89.87000 |
| LogP | 6.03540 |
| InChIKey | RWNAOXLCVXJMGM-UHFFFAOYSA-N |
| SMILES | CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ncnc5[nH]c(C)cc45)c3)cc2C(F)(F)F)CC1 |
| Storage condition | 2-8℃ |
| N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-((6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)benzamide |
| B-Raf inhibitor| |
| CS-1099 |
| N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide |
| B-Raf inhibitor |