BRAF V600E/CRAF-IN-2

Modify Date: 2025-08-25 18:10:37

BRAF V600E/CRAF-IN-2 Structure
BRAF V600E/CRAF-IN-2 structure
 Common Name BRAF V600E/CRAF-IN-2
CAS Number 2499499-62-4 Molecular Weight 549.59
Density N/A Boiling Point N/A
Molecular Formula C30H30F3N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BRAF V600E/CRAF-IN-2


BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].

 Names

Name BRAF V600E/CRAF-IN-2

 BRAF V600E/CRAF-IN-2 Biological Activity

Description BRAF V600E/CRAF-IN-2 (Compound 9c) is a potent inhibitor of BRAF V600E/CRAF with IC50s of 0.888 and 0.229 μM, respectively. BRAF V600E/CRAF-IN-2 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-2 has the potential for the research of cancer diseases[1].
Related Catalog
References

[1]. El-Damasy AK,et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.

 Chemical & Physical Properties

Molecular Formula C30H30F3N5O2
Molecular Weight 549.59
InChIKey OTASYYGEHSXRJI-UHFFFAOYSA-N
SMILES CCN1CCN(c2cc(C(=O)Nc3cccc(Nc4ccc5c(OC)cccc5n4)c3)cc(C(F)(F)F)c2)CC1
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BRAF V600E/CRAF-IN-1
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PF-06855800
1989620-04-3
BI-3406
2230836-55-0
PARP-2/1-IN-2
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SEL120-34A
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CDK2/4/6-IN-2
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K-Ras G12C-IN-2
1629267-75-9
ST 045849
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A 33
915082-52-9
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[(3-Methyl-4-propoxyphenyl)sulfonyl](1,1,3,3-tetramethylbutyl)amine
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6-Bromo-N-[2-(4-tert-butylphenyl)-2-(dimethylamino)ethyl]-4-oxochromene-2-carboxamide;hydrochloride
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5-Methylthiophene-2-carboximidamide hydrochloride
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Chemsrc provides BRAF V600E/CRAF-IN-2(CAS#:2499499-62-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BRAF V600E/CRAF-IN-2 are included as well.>> amp version: BRAF V600E/CRAF-IN-2

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