5,7-Dichlorokynurenic acid

Modify Date: 2024-01-05 13:04:09

5,7-Dichlorokynurenic acid Structure
5,7-Dichlorokynurenic acid structure
Common Name 5,7-Dichlorokynurenic acid
CAS Number 131123-76-7 Molecular Weight 258.05800
Density N/A Boiling Point N/A
Molecular Formula C10H5Cl2NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5,7-Dichlorokynurenic acid


5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].

 Names

Name 5,7-dichlorokynurenic acid sodium salt
Synonym More Synonyms

 5,7-Dichlorokynurenic acid Biological Activity

Description 5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].
Related Catalog
References

[1]. D McNamara, et al.  5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20.

 Chemical & Physical Properties

Molecular Formula C10H5Cl2NO3
Molecular Weight 258.05800
Exact Mass 256.96500
PSA 70.42000
LogP 2.94540
Appearance of Characters solid | light yellow
Storage condition Desiccate at RT
Water Solubility 0.1 M NaOH: soluble

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
WGK Germany 3
HS Code 2933499090

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5,7-DICHLOROKYNURENIC ACID
5,7-Dichlorokynurenic acid sodium salt
5,7-Dichorokynurenic acid
5,7-dichloro-4-hydroxy-2-carboxyquinoline
MFCD00674925
5,7-DCKA
5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid
5,7-DICHLOROKYNURENIC ACID POTENT EXCITA TORY AMI
2-Quinolinecarboxylic acid,5,7-dichloro-4-hydroxy
5,7-dichlorokynurenic acid sodium
5,7-Dichloroquinurenic acid
5,7-Dichlor-4-hydroxy-chinolin-2-carbonsaeure