5,7-Dichlorokynurenic acid

Names

[ Name ]:
5,7-Dichlorokynurenic acid

[Synonym ]:
5,7-DICHLOROKYNURENIC ACID
5,7-Dichlorokynurenic acid sodium salt
5,7-Dichorokynurenic acid
5,7-dichloro-4-hydroxy-2-carboxyquinoline
MFCD00674925
5,7-DCKA
5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID
5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid
5,7-DICHLOROKYNURENIC ACID POTENT EXCITA TORY AMI
2-Quinolinecarboxylic acid,5,7-dichloro-4-hydroxy
5,7-dichlorokynurenic acid sodium
5,7-Dichloroquinurenic acid
5,7-Dichlor-4-hydroxy-chinolin-2-carbonsaeure

Biological Activity

[Description]:

5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₅Cl₂NO₃

[ Molecular Weight ]:
258.05800

[ Exact Mass ]:
256.96500

[ PSA ]:
70.42000

[ LogP ]:
2.94540

[ Appearance of Characters ]:
solid | light yellow

[ Storage condition ]:
Desiccate at RT

[ Water Solubility ]:
0.1 M NaOH: soluble

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ HS Code ]:
2933499090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%