N-chlorosuccinimide

Modify Date: 2024-01-02 15:22:43

N-chlorosuccinimide Structure
N-chlorosuccinimide structure
Common Name N-chlorosuccinimide
CAS Number 128-09-6 Molecular Weight 133.533
Density 1.5±0.1 g/cm3 Boiling Point 200.5±23.0 °C at 760 mmHg
Molecular Formula C4H4ClNO2 Melting Point 148-150 °C(lit.)
MSDS Chinese USA Flash Point 75.1±22.6 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name N-chlorosuccinimide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 200.5±23.0 °C at 760 mmHg
Melting Point 148-150 °C(lit.)
Molecular Formula C4H4ClNO2
Molecular Weight 133.533
Flash Point 75.1±22.6 °C
Exact Mass 132.993057
PSA 37.38000
LogP -0.87
Vapour Pressure 0.3±0.4 mmHg at 25°C
Index of Refraction 1.532

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY1013500
CHEMICAL NAME :
2,5-Pyrrolidinedione, 1-chloro-
CAS REGISTRY NUMBER :
128-09-6
BEILSTEIN REFERENCE NO. :
0113915
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C4-H4-Cl-N-O2
MOLECULAR WEIGHT :
133.54
WISWESSER LINE NOTATION :
T5VNVTJ BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15 gm/kg/40D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5800 mg/kg/5W-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
REFERENCE :
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 59,541,1944 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
840 mg/kg/70W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 53,695,1974

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R22;R34
Safety Phrases S26-S36/37/39-S45-S37/39
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS UY1013500
Packaging Group III
Hazard Class 8
HS Code 2933990090

 Synthetic Route

~96%

N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: Synlett, , # 2 p. 194 - 200

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N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: EP1338595 A2, ;

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N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: Journal of the American Chemical Society, , vol. 76, p. 3856

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N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: Journal of the Chemical Society [Section] B: Physical Organic, , p. 626 - 631

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N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: Journal of the Chemical Society [Section] B: Physical Organic, , p. 626 - 631

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N-chlorosuccinimide Structure

N-chlorosuccinimide

CAS#:128-09-6

Literature: Chemische Berichte, , vol. 19, p. 2268

 Customs

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

succinimide, N-chloro-
Chlorosuccinimide
EINECS 204-878-8
N-chlorobutanimide
1-Chloro-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-chloro-
Succinimide, N-chloro- (8CI)
1-chloropyrrolidine-2,5-dione
N-Chlorosuccinimide
MFCD00005511
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