SGK1-IN-1

Modify Date: 2025-08-27 15:16:40

SGK1-IN-1 structure	Common Name	SGK1-IN-1
	CAS Number	1279829-87-6	Molecular Weight	418.83
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₂ClFN₆O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SGK1-IN-1

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

Name	SGK1-IN-1

Description	SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> SGK Research Areas >> Others
Target	IC50: 1 nM (SGK-1)[1][2].
In Vitro	SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].
References	[1]. ARYL SULFONOHYDRAZIDES. WO 2013041119 A1. [2]. Halland N, et al. Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8.

Molecular Formula	C₁₇H₁₂ClFN₆O₂S
Molecular Weight	418.83

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SGK1-IN-1
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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