1279829-87-6

1279829-87-6 structure

1279829-87-6 structure

Name: SGK1-IN-1
Chemical Name: SGK1-IN-1
CAS Number: 1279829-87-6
Molecular Formula: C₁₇H₁₂ClFN₆O₂S
Molecular Weight: 418.83
Catalog: Signaling Pathways Metabolic Enzyme/Protease SGK
Create Date: 2019-02-11 18:40:02
Modify Date: 2024-01-10 18:34:37
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

Name	SGK1-IN-1

Description	SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> SGK Research Areas >> Others
Target	IC50: 1 nM (SGK-1)[1][2].
In Vitro	SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].
References	[1]. ARYL SULFONOHYDRAZIDES. WO 2013041119 A1. [2]. Halland N, et al. Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8.

Molecular Formula	C₁₇H₁₂ClFN₆O₂S
Molecular Weight	418.83