MC 1046

Modify Date: 2024-01-12 19:10:21

MC 1046 Structure
MC 1046 structure
Common Name MC 1046
CAS Number 126860-83-1 Molecular Weight 410.589
Density 1.1±0.1 g/cm3 Boiling Point 584.2±50.0 °C at 760 mmHg
Molecular Formula C27H38O3 Melting Point N/A
MSDS N/A Flash Point 321.1±26.6 °C

 Use of MC 1046


MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

 Names

Name MC 1046
Synonym More Synonyms

 MC 1046 Biological Activity

Description MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value:Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.
Related Catalog
References

[1]. Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.

[2]. Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.

[3]. Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111

[4]. P.J. Marie, D. Connes, M. Hott, L. Miravet. Comparative effects of a novel Vitamin D Analogue MC-903 and 1,25-dihydroxyvitamin D3 on alkaline phosphatase activity, osteocalcin and DNA synthesis by human osteoblastic cells in culture. Bone. Volume 11, Issue 3, 1990, Pages 171-179

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 584.2±50.0 °C at 760 mmHg
Molecular Formula C27H38O3
Molecular Weight 410.589
Flash Point 321.1±26.6 °C
Exact Mass 410.282104
LogP 4.95
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.574
Storage condition 2-8℃

 Synonyms

2-Penten-1-one, 1-cyclopropyl-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-, (2E,4R)-
G70BS4HF9Z
MFCD00872035
MC-1046
(1S,3R,5Z,7E,22E)-1,3-Dihydroxy-26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraen-24-one
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