MC-SN38

Modify Date: 2025-08-25 17:06:37

MC-SN38 structure	Common Name	MC-SN38
	CAS Number	1473403-87-0	Molecular Weight	585.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₁N₃O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MC-SN38

MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].

Name	MC-SN38

Description	MC-SN38 is a drug-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody drug conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56. [2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Description

Related Catalog

Research Areas >> Cancer

References

[1]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56.

[2]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.

Molecular Formula	C₃₂H₃₁N₃O₈
Molecular Weight	585.60

Hazard Codes	Xi

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MC-SN38

Use of MC-SN38

Names

MC-SN38 Biological Activity

Chemical & Physical Properties

Safety Information

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.