MC-70

Modify Date: 2024-01-02 12:51:02

MC-70 structure	Common Name	MC-70
	CAS Number	1031367-64-2	Molecular Weight	375.46
	Density	1.2±0.1 g/cm3	Boiling Point	536.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₅NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	278.3±30.1 °C

Use of MC-70

MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].

Name	MC70
Synonym	More Synonyms

Description	MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein
Target	EC50: 0.69 µM (P-glycoprotein)[1]
References	[1]. Stefano Guglielmo, et al. Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jul 28;59(14):6729-38. [2]. Amalia Azzariti, et al. MC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment. Eur J Pharmacol. 2011 Nov 16;670(1):74-84.

Density	1.2±0.1 g/cm3
Boiling Point	536.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₄H₂₅NO₃
Molecular Weight	375.46
Flash Point	278.3±30.1 °C
Exact Mass	375.183441
LogP	4.22
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.617

4'-[(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)methyl]-4-biphenylol

4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol; MC70

4'-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl]biphenyl-4-ol

[1,1'-Biphenyl]-4-ol, 4'-[(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)methyl]-

DC Chemicals Limited
China
Product Name: MC-70
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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