Atorvastatin Acetonide tert-Butyl Ester

Modify Date: 2025-08-21 19:07:22

Atorvastatin Acetonide tert-Butyl Ester structure	Common Name	Atorvastatin Acetonide tert-Butyl Ester
	CAS Number	125971-95-1	Molecular Weight	654.810
	Density	1.1±0.1 g/cm3	Boiling Point	678.0±55.0 °C at 760 mmHg
	Molecular Formula	C₄₀H₄₇FN₂O₅	Melting Point	144-148ºC
	MSDS	USA	Flash Point	363.9±31.5 °C

Use of Atorvastatin Acetonide tert-Butyl Ester

Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids[1].

Name	tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
Synonym	More Synonyms

Description	Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Process for preparing amorphous (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid. WO2005063741A1.

Density	1.1±0.1 g/cm3
Boiling Point	678.0±55.0 °C at 760 mmHg
Melting Point	144-148ºC
Molecular Formula	C₄₀H₄₇FN₂O₅
Molecular Weight	654.810
Flash Point	363.9±31.5 °C
Exact Mass	654.346924
PSA	78.79000
LogP	7.78
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.569

Atorvastatin Acetonide tert-Butyl Ester MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 8
CAS#:125971-86-0 tert-butyl 2-((... CAS#:125971-96-2 Benzenebutanami... CAS#:125971-94-0 (4R,6R)-tert-Bu... CAS#:805242-36-8 4,4,6-trimethyl...
CAS#:67-63-0 Isopropanol CAS#:459-57-4 4-Fluorobenzaldehyde CAS#:124401-38-3 4-Methyl-3-oxo-... CAS#:100-52-7 Benzaldehyde
DownStream 5
CAS#:125995-03-1 Atorvastatin lactone CAS#:134395-00-9 Atorvastatin te... CAS#:134523-00-5 Atorvastatin CAS#:134523-01-6 Atorvastatin Sodium
CAS#:581772-29-4 Atorvastatin Ac...

tert-butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Atorvastatin Acetonide tert-Butyl Ester

MFCD08458280

T6O COTJ B1 B1 D1VOX1&1&1 F2- AT5NJ BY1&1 CVMR& DR ER DF &&(4R,6R)- Form

Atorvastatin intermediate L1

tert-Butyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-

2-Methyl-2-propanyl [(4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Atorvastatin calciuM interMediate

(4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE

Atorvastatin Impurity 30