LY 233053

Modify Date: 2024-01-07 20:01:26

LY 233053 structure	Common Name	LY 233053
	CAS Number	125546-04-5	Molecular Weight	211.22
	Density	1.398g/cm3	Boiling Point	488.9ºC at 760mmHg
	Molecular Formula	C₈H₁₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	249.5ºC

Use of LY 233053

LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy[1][2].

Name	LY 233053,(2R,4S)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylicacid

Description	LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDA Receptor
In Vivo	LY 233053 (0.5 和 5 mg/kg) 对电惊厥阈值没有影响，但增强了抗癫痫药物的抗惊厥作用[1]。 LY 233053 (5mg/kg) 与卡马西平、二苯基苯妥英或苯巴比妥联合使用可提供 50% 的最大电击保护，但会导致长期记忆损伤[1]。 LY233053 (静脉团注，100mg/kg; 在可逆脊髓缺血后 5、30 或 60 分钟内给药) 对限制缺血性损伤是有效的，但如果在新西兰大白兔损伤后 60 分钟内不开始治疗，保护作用就会丧失[2]。
References	[1]. 1.K K Borowicz, et al. Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Epilepsia. 1996 Jul;37(7):618-24. [2]. K P Madden, et al. Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J Neurosurg. 1992 Jan;76(1):106-10.

Density	1.398g/cm3
Boiling Point	488.9ºC at 760mmHg
Molecular Formula	C₈H₁₃N₅O₂
Molecular Weight	211.22
Flash Point	249.5ºC
Exact Mass	211.10700
PSA	103.79000
Vapour Pressure	2.25E-10mmHg at 25°C
Index of Refraction	1.581

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2R,4S)-4-(2H-tetrazol-5-ylmethyl)piperidine-2-carboxylic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

LY 233053 suppliers

LY 233053 price