TUG-469
Modify Date: 2024-02-28 18:44:57
TUG-469 structure
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Common Name | TUG-469 | ||
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| CAS Number | 1236109-67-3 | Molecular Weight | 345.434 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 532.7±38.0 °C at 760 mmHg | |
| Molecular Formula | C23H23NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 275.9±26.8 °C | |
Use of TUG-469TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2]. |
| Name | 3-(4-{[(2'-Methyl-3-biphenylyl)methyl]amino}phenyl)propanoic acid |
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| Synonym | More Synonyms |
| Description | TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2]. |
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| Related Catalog | |
| In Vitro | TUG-469 (0-10 μM) shows efficacy to hFFA1 with an pEC50 value of 7.73[1]. TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation[1]. TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively[2]. TUG-469 (5 μM; 30 min) leds a significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM)[2]. |
| In Vivo | TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level[2]. Animal Model: Male NZO mice with glucose administration[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration Result: Reduced the blood glucose level. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 532.7±38.0 °C at 760 mmHg |
| Molecular Formula | C23H23NO2 |
| Molecular Weight | 345.434 |
| Flash Point | 275.9±26.8 °C |
| Exact Mass | 345.172882 |
| LogP | 4.97 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Storage condition | -20°C |
| 3-(4-{[(2'-Methyl-3-biphenylyl)methyl]amino}phenyl)propanoic acid |
| Benzenepropanoic acid, 4-[[(2'-methyl[1,1'-biphenyl]-3-yl)methyl]amino]- |