1236109-67-3

1236109-67-3 structure

Name: TUG-469
Chemical Name: 3-(4-{[(2'-Methyl-3-biphenylyl)methyl]amino}phenyl)propanoic acid
CAS Number: 1236109-67-3
Molecular Formula: C₂₃H₂₃NO₂
Molecular Weight: 345.434
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2018-06-06 13:32:44
Modify Date: 2024-02-28 18:44:57
TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2].

Name	3-(4-{[(2'-Methyl-3-biphenylyl)methyl]amino}phenyl)propanoic acid
Synonyms	3-(4-{[(2'-Methyl-3-biphenylyl)methyl]amino}phenyl)propanoic acid Benzenepropanoic acid, 4-[[(2'-methyl[1,1'-biphenyl]-3-yl)methyl]amino]-

Description	TUG-469 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist with an EC50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease
In Vitro	TUG-469 (0-10 μM) shows efficacy to hFFA1 with an pEC50 value of 7.73[1]. TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation[1]. TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively[2]. TUG-469 (5 μM; 30 min) leds a significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM)[2].
In Vivo	TUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level[2]. Animal Model: Male NZO mice with glucose administration[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration Result: Reduced the blood glucose level.