2247372-59-2

2247372-59-2 structure

Name: TUG-1375
Chemical Name: TUG-1375
CAS Number: 2247372-59-2
Molecular Formula: C₂₂H₁₉ClN₂O₄S
Molecular Weight: 442.92
Catalog: Research Areas Metabolic Disease
Create Date: 2019-06-02 09:03:49
Modify Date: 2024-01-10 22:54:41
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].

Name	TUG-1375

Description	TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	pKi: 6.69 (FFA2)[1]
In Vitro	TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1].
References	[1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550.