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1374516-07-0

1374516-07-0 structure
1374516-07-0 structure
  • Name: TUG 891
  • Chemical Name: 3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid
  • CAS Number: 1374516-07-0
  • Molecular Formula: C23H21FO3
  • Molecular Weight: 364.40900
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2017-06-23 15:02:13
  • Modify Date: 2024-01-02 19:30:02
  • TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.

Name 3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid
Synonyms tug-770
TUG 891
TUG-891
TUG891
Description TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.
Related Catalog
In Vitro TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].
References

[1]. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25.

Molecular Formula C23H21FO3
Molecular Weight 364.40900
Exact Mass 364.14700
PSA 46.53000
LogP 5.39730
Storage condition 2-8℃
Precursor  2

DownStream  0