Dihydrexidine

Modify Date: 2024-01-02 15:46:05

Dihydrexidine Structure
Dihydrexidine structure
Common Name Dihydrexidine
CAS Number 123039-93-0 Molecular Weight 303.78300
Density 1.267g/cm3 Boiling Point 488.3ºC at 760mmHg
Molecular Formula C17H17NO2 Melting Point N/A
MSDS N/A Flash Point 190.5ºC

 Use of Dihydrexidine


Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3].

 Names

Name 5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
Synonym More Synonyms

 Dihydrexidine Biological Activity

Description Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3].
Related Catalog
Target

IC50: 10 nM (D1 dopamine receptor)[1]

References

[1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3.

[2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93.

[3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42.

 Chemical & Physical Properties

Density 1.267g/cm3
Boiling Point 488.3ºC at 760mmHg
Molecular Formula C17H17NO2
Molecular Weight 303.78300
Flash Point 190.5ºC
Exact Mass 303.10300
PSA 52.49000
LogP 3.77850
Vapour Pressure 3.7E-10mmHg at 25°C

 Synonyms

dihydrexidine
dar0100a
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