Dihydrexidine

Names

[ Name ]:
Dihydrexidine

[Synonym ]:
dihydrexidine
dar0100a

Biological Activity

[Description]:

Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

IC50: 10 nM (D1 dopamine receptor)[1]

[References]

[1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3.

[2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93.

[3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42.

Chemical & Physical Properties

[ Density]:
1.267g/cm3

[ Boiling Point ]:
488.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₇NO₂

[ Molecular Weight ]:
303.78300

[ Flash Point ]:
190.5ºC

[ Exact Mass ]:
303.10300

[ PSA ]:
52.49000

[ LogP ]:
3.77850

[ Vapour Pressure ]:
3.7E-10mmHg at 25°C

Related Compounds

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