GSK 2033

Modify Date: 2024-01-08 16:25:58

GSK 2033 structure	Common Name	GSK 2033
	CAS Number	1221277-90-2	Molecular Weight	591.661
	Density	1.3±0.1 g/cm3	Boiling Point	734.7±70.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₂₈F₃NO₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	398.1±35.7 °C

Use of GSK 2033

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.

Name	2,4,6-Trimethyl-N-{[3'-(methylsulfonyl)-4-biphenylyl]methyl}-N-{[5-(trifluoromethyl)-2-furyl]methyl}benzenesulfonamide
Synonym	More Synonyms

Description	GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Metabolic Disease
Target	pIC50: 7 (LXRα), 7.4 (LXRβ)[1]
In Vitro	GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC50s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC50s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1[2].
In Vivo	One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels. Plasma triglyceride levels are also unaffected by treatment with GSK2033[2].
Cell Assay	HepG2 cells are maintained in minimal essential medium supplemented with 10% FBS and antibiotics. HepG2 cells are then treated for 24 h with GSK2033 followed by assessment of expression of genes by qPCR[2].
Animal Admin	21-week old male C57BL6 DIO mice are used. Animals are individually housed and fed a high fat diet (60% kcal/fat diet, 20% carbohydrate) for the duration of the experiment that includes GSK2033 administration for 28 days (30 mg/kg, q. d, i. p.). Body weight and food intake are monitored daily[2].
References	[1]. Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6. [2]. Griffett K, et al. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

Density	1.3±0.1 g/cm3
Boiling Point	734.7±70.0 °C at 760 mmHg
Molecular Formula	C₂₉H₂₈F₃NO₅S₂
Molecular Weight	591.661
Flash Point	398.1±35.7 °C
Exact Mass	591.136108
LogP	6.62
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.572
Storage condition	2-8℃

2,4,6-Trimethyl-N-{[3'-(methylsulfonyl)-4-biphenylyl]methyl}-N-{[5-(trifluoromethyl)-2-furyl]methyl}benzenesulfonamide

Benzenesulfonamide, 2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-N-[[5-(trifluoromethyl)-2-furanyl]methyl]-

GSK2033

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK2033
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GSK2033
Price: $650.0/100mg $950.0/250mg $1900.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: GSK2033
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: $156/10mM*1mLinDMSO

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GSK 2033

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