Thalidomide D4
Modify Date: 2025-08-20 14:45:38
Thalidomide D4 structure
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Common Name | Thalidomide D4 | ||
|---|---|---|---|---|
| CAS Number | 1219177-18-0 | Molecular Weight | 262.25400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H6D4N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide D4Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2]. |
| Name | 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Thalidomide D4 is a deuterium labeled Thalidomide. Thalidomide is initially promoted as a sedative, inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2]. |
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| Related Catalog | |
| Target |
Kd: ~250 nM (CRL4CRBN)[1] |
| References |
| Molecular Formula | C13H6D4N2O4 |
|---|---|
| Molecular Weight | 262.25400 |
| Exact Mass | 262.08900 |
| PSA | 87.04000 |
| LogP | 0.30160 |
| |A-Phthalimidoglutarimide-d4 |
| Myrin-d4 |
| 3-Phthalimidoglutarimide-d4 |
| Celgene-d4 |
| Contergan-d4 |
| Thalidomide-d4 |
| Distaval-d4 |
| Kevadon-d4 |