4-Acetamidobenzenesulfonyl chloride

Modify Date: 2024-01-03 19:30:21

4-Acetamidobenzenesulfonyl chloride Structure
4-Acetamidobenzenesulfonyl chloride structure
Common Name 4-Acetamidobenzenesulfonyl chloride
CAS Number 121-60-8 Molecular Weight 233.672
Density 1.5±0.1 g/cm3 Boiling Point 426.8±28.0 °C at 760 mmHg
Molecular Formula C8H8ClNO3S Melting Point 142-145 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 211.9±24.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name N-Acetylsulfanilyl chloride
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 426.8±28.0 °C at 760 mmHg
Melting Point 142-145 °C (dec.)(lit.)
Molecular Formula C8H8ClNO3S
Molecular Weight 233.672
Flash Point 211.9±24.0 °C
Exact Mass 232.991348
PSA 71.62000
LogP 1.55
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.586
Water Solubility SLIGHTLY SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB8837500
CHEMICAL NAME :
Benzenesulfonyl chloride, 4-(acetylamino)-
CAS REGISTRY NUMBER :
121-60-8
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H8-Cl-N-O3-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3200 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533583

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H314-H335
Precautionary Statements P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45-S28B
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS DB8837500
Packaging Group II
Hazard Class 8
HS Code 29242995

 Synthetic Route

~95%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Ludwig, Miroslav; Stverka, Pavel Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, # 8 p. 1205 - 1214

~88%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Tan, Shiyu; Yang, Yang; Luo, Ziping; Zhao, Shuo; Huang, Dafu; Zhang, Jun; Dong, Lichun; Wang, Gang Chemical Papers, 2011 , vol. 65, # 4 p. 510 - 518

~86%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J. European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14

~71%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Blotny, Grzegorz Tetrahedron Letters, 2003 , vol. 44, # 7 p. 1499 - 1501

~%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Asian Journal of Chemistry, , vol. 24, # 4 p. 1872 - 1878

~%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Arquivos Biol. Sao Paulo, , vol. 28, p. 147,150

~%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Yakugaku Zasshi, , vol. 68, p. 278,281 Chem.Abstr., , p. 9498

~%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Arquivos Biol. Sao Paulo, , vol. 28, p. 147,150

~%

4-Acetamidobenzenesulfonyl chloride Structure

4-Acetamidobenz...

CAS#:121-60-8

Literature: Yakugaku Zasshi, , vol. 68, p. 278,281 Chem.Abstr., , p. 9498

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

4-Acetamidobenzenesulfonyl Chloride
Sulfanilyl chloride, N-acetyl-
P-ACETAMIDOBENZENE SULFONYL CHLORIDE ASC
4-ACETAMIDOBENZENESULFONYLCHLORIDE
P-ACETYLSULPHANILYL CHLORIDE
ASC
UNII-LIX4M9AIVM
p-Acetamidophenylsulfonyl chloride
4-ACETAMINOBENZENESULFONYL CHLORIDE
N-Acetylsulfanilylchloride
p-Acetylaminobenzenesulfonyl chloride
EINECS 204-485-1
4-Acetamidophenylsulfonyl chloride
N-Acetylsulfanilyl chloride
N-Acetylsulfanyl Chloride
p-Acetaminobenzenesulfonyl chloride
4-(ACETYLAMINO)BENZENESULFONYL CHLORIDE
p-Acetamidobenzenesulfonyl chloride
4-Chlorosulfonylacetanilide
4-ACETAMIDOBENZENESULPHONYL CHLORIDE/N-ACETYLSULPHANILYL CHLORIDE] 121-60-8
N-ACETYLSULPHANILYL CHLORIDE
4-ACETAMIDEBENZENESULFONYL CHLORIDE
Acetanilide-p-sulfonyl chloride
4-ACETAMIDOBENZENE SULFONYL CHLORIDE
N-Acetyl sulfanilyl chloride
p-(Chlorosulfonyl)acetanilide
4-ACETAMIDOBENZENESULFONYL CHLORIDE FOR SYNTHESIS
4-ACETAMIDOBENZENESULPHONYL CHLORIDE
4-Acetamidobenzene-1-Sulfonyl Chloride
MFCD00007442
Benzenesulfonyl chloride, 4-(acetylamino)-
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