NAV 26

Modify Date: 2024-01-11 10:36:42

NAV 26 Structure
NAV 26 structure
Common Name NAV 26
CAS Number 1198160-14-3 Molecular Weight 434.41
Density 1.4±0.1 g/cm3 Boiling Point 607.7±55.0 °C at 760 mmHg
Molecular Formula C22H21F3N2O4 Melting Point N/A
MSDS N/A Flash Point 321.3±31.5 °C

 Use of NAV 26


NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].

 Names

Name 3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide
Synonym More Synonyms

 NAV 26 Biological Activity

Description NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].
Related Catalog
Target

Nav1.7:0.37 μM (IC50)

References

[1]. Istvan Macsari, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 607.7±55.0 °C at 760 mmHg
Molecular Formula C22H21F3N2O4
Molecular Weight 434.41
Flash Point 321.3±31.5 °C
Exact Mass 434.145355
LogP 1.67
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.571

 Synonyms

3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide
1H-Isoindole-1-carboxamide, 2,3-dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-
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