NAV 26

Names

[ CAS No. ]:
1198160-14-3

[ Name ]:
NAV 26

[Synonym ]:
3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide
1H-Isoindole-1-carboxamide, 2,3-dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-

Biological Activity

[Description]:

NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Neurological Disease

[Target]

Nav1.7:0.37 μM (IC50)

[References]

[1]. Istvan Macsari, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
607.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₁F₃N₂O₄

[ Molecular Weight ]:
434.41

[ Flash Point ]:
321.3±31.5 °C

[ Exact Mass ]:
434.145355

[ LogP ]:
1.67

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.571

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.