1198160-14-3

1198160-14-3 structure

Name: NAV 26
Chemical Name: 3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide
CAS Number: 1198160-14-3
Molecular Formula: C₂₂H₂₁F₃N₂O₄
Molecular Weight: 434.41
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2021-01-15 18:59:29
Modify Date: 2024-01-11 10:36:42
NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].

Name	3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide
Synonyms	3-Oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[4-(trifluoromethoxy)benzyl]-1-isoindolinecarboxamide 1H-Isoindole-1-carboxamide, 2,3-dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-

Description	NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	Nav1.7:0.37 μM (IC50)
References	[1]. Istvan Macsari, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.