29261-12-9

29261-12-9 structure

Name: 25,26-Dihydroxyvitamin D3
Chemical Name: 25,26-Dihydroxy Vitamin D3
CAS Number: 29261-12-9
Molecular Formula: C₂₇H₄₄O₃
Molecular Weight: 416.63600
Catalog: Signaling Pathways Vitamin D Related VD/VDR
Create Date: 2017-04-13 13:18:44
Modify Date: 2025-08-31 05:01:10
25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.

Name	25,26-Dihydroxy Vitamin D3
Synonyms	(5E,7E)-9,10-Secocholesta-5,7,10-triene-3,25,26-triol 25,26-Dihydroxyvitamin D3

Description	25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. DeLuca HF, et al. 25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. Biochemistry. 1970 Nov 24;9(24):4776-80. [2]. Miravet L, et al. The biological activity of synthetic 25,26-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in vitamin D-deficient rats. Calcif Tissue Res. 1976 Dec 2;21(3):145-52. [3]. Fraher LJ, et al. Determination of circulating 25,26-dihydroxycholecalciferol in man by radioimmunoassay. Clin Sci (Lond). 1980 Oct;59(4):257-63.

Density	1.06g/cm3
Boiling Point	575.3ºC at 760mmHg
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.63600
Flash Point	243.7ºC
Exact Mass	416.32900
PSA	60.69000
LogP	5.70630
Vapour Pressure	1.24E-15mmHg at 25°C
Index of Refraction	1.548
Storage condition	2-8℃

Hazard Codes	T: Toxic;
Risk Phrases	23/24/25-63
Safety Phrases	36/37-45
RIDADR	UN2811 6.1/PG 2

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