ML 604440

Modify Date: 2024-01-10 11:32:15

ML 604440 structure	Common Name	ML 604440
	CAS Number	1140517-08-3	Molecular Weight	388.19
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₄BF₃N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML 604440

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

Name	ML604440

Description	ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
Target	proteasome β1i (LMP2) subunit inhibitor[1]
References	[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209 [2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.

Molecular Formula	C₁₇H₂₄BF₃N₂O₄
Molecular Weight	388.19

DC Chemicals Limited
China
Product Name: ML 604440
Price: $1100.0/100mg $2200.0/250mg $4400.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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