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ML 604440

Names

[ CAS No. ]:
1140517-08-3

[ Name ]:
ML 604440

Biological Activity

[Description]:

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1].ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[Target]

proteasome β1i (LMP2) subunit inhibitor[1]


[References]

[1]. de Bruin G, et al. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem. 2014 Jul 24;57(14):6197-209

[2]. Basler M, et al. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 2018 Dec;19(12). pii: e46512.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H24BF3N2O4

[ Molecular Weight ]:
388.19

Related Compounds