CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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RS7534500
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CHEMICAL NAME :
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Oxytocin, 8-L-arginine-
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CAS REGISTRY NUMBER :
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113-80-4
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C43-H67-N15-O12-S2
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MOLECULAR WEIGHT :
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1050.37
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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625 ug/kg
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SEX/DURATION :
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male 5 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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REFERENCE :
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BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 37,935,1987
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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80 ug/kg
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SEX/DURATION :
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female 19 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - menstrual cycle changes or disorders
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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80 ug/kg
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SEX/DURATION :
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female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - abortion
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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120 ug/kg
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SEX/DURATION :
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male 3 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Unreported
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DOSE :
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80 ug/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina
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REFERENCE :
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PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 133,1254,1970
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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24 ug/kg
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SEX/DURATION :
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male 3 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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REFERENCE :
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INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 19,103,1974
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