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198284-64-9

198284-64-9 structure
198284-64-9 structure
  • Name: GAP 27 acetate salt
  • Chemical Name: Gap 27
  • CAS Number: 198284-64-9
  • Molecular Formula: C60H101N15O17
  • Molecular Weight: 1304.53000
  • Catalog: Peptides
  • Create Date: 2016-05-31 23:39:06
  • Modify Date: 2024-01-02 10:36:52
  • Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
Name Gap 27
Synonyms Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile
M.W. 1304.55 C60H101N15O17
H-SER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE-OHSER-ARG-PRO-THR-GLU-LYS-THR-ILE-PHE-ILE-ILE
Description Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
Related Catalog
In Vitro Gap 27 causes a remarked decrease in the number of both TRAP-positive mononuclear and multinucleated rat osteoclasts cultured on bovine bone slices. The activity of the remaining osteoclasts is found to be diminished by measuring the percentage of osteoclasts with actin rings of all TRAP-positive cells. In addition, the resorbed area in the treated cultures is greatly diminished[1]. Incubation of the carotid artery with the gap junction inhibitor Gap 27 (500 μM) essentially abolishes the hyperpolarization to acetylcholine but it is without effect on that to levcromakalim. In the guinea-pig isolated internal carotid artery, Gap 27 inhibits acetylcholine-induced, endothelium-dependent hyperpolarizations[2].
In Vivo Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta. [3].
Cell Assay Bone cell cultures are cultured for 48 hours with three different treatments (control, heptanol and Gap 27). After the culture period, bone slices are fixed. The cells are stained for tartrate-resistant acid phosphatase (TRAP). To visualise the nuclei, the cells are incubated with the DNA-binding fluorochrome Hoechst 33258 (1 mg/mL stock diluted 1:800 in PBS) for 10 minutes at room temperature. The numbers of mononuclear and multinucleated TRAP-positive cells on each bone slice are counted[1].
References

[1]. Ilvesaro J, et al. Connexin-mimetic peptide Gap 27 decreases osteoclastic activity. BMC Musculoskelet Disord. 2001;2:10.

[2]. Edwards G, et al. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br J Pharmacol. 1999 Dec;128(8):1788-94.

[3]. Chaytor AT,e t al. Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J Physiol. 1998 Apr 15;508 ( Pt 2):561-73.
Molecular Formula C60H101N15O17
Molecular Weight 1304.53000
Exact Mass 1303.75000
PSA 531.44000
LogP 2.19200
Storage condition -20°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22
RIDADR NONH for all modes of transport

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title: CAS No. 198284-64-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1104933.html

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