TR-100
Modify Date: 2025-08-27 19:01:29
TR-100 structure
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Common Name | TR-100 | ||
|---|---|---|---|---|
| CAS Number | 1128165-86-5 | Molecular Weight | 422.606 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 620.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H38N4O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 329.1±31.5 °C | |
Use of TR-100TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models. |
| Name | TR100 |
|---|---|
| Synonym | More Synonyms |
| Description | TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models. |
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| References | References 1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82. 2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816. 3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. 4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604. View Related Products by Target Microtubule/Tubulin |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 620.6±55.0 °C at 760 mmHg |
| Molecular Formula | C26H38N4O |
| Molecular Weight | 422.606 |
| Flash Point | 329.1±31.5 °C |
| Exact Mass | 422.304565 |
| LogP | 5.88 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.547 |
| InChIKey | XXRLIGWROLDOLS-ZBJSNUHESA-N |
| SMILES | CCCCCCCCNC(=O)C(C#N)=Cc1c(C)n(CCCN(C)C)c2ccccc12 |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |
| TR100 |
| 2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide |
| (2Z)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl}-N-octylacrylamide |
| 2-Propenamide, 2-cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-, (2Z)- |