TR-100

Names

[ Name ]:
TR-100

[Synonym ]:
TR100
2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide
(2Z)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl}-N-octylacrylamide
2-Propenamide, 2-cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-, (2Z)-

Biological Activity

[Description]:

TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.

[References]

References 1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82. 2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816. 3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. 4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604. View Related Products by Target Microtubule/Tubulin

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
620.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₃₈N₄O

[ Molecular Weight ]:
422.606

[ Flash Point ]:
329.1±31.5 °C

[ Exact Mass ]:
422.304565

[ LogP ]:
5.88

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.547

Safety Information

[ Hazard Statements ]:
H413

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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