1128165-86-5
1128165-86-5 structure
- Name: TR-100
- Chemical Name: TR100
- CAS Number: 1128165-86-5
- Molecular Formula: C26H38N4O
- Molecular Weight: 422.606
- Create Date: 2020-01-11 12:11:53
- Modify Date: 2024-01-10 13:50:31
-
TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.
| Name | TR100 |
|---|---|
| Synonyms |
TR100
2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide (2Z)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl}-N-octylacrylamide 2-Propenamide, 2-cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-, (2Z)- |
| Description | TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models. |
|---|---|
| References | References 1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82. 2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816. 3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565. 4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604. View Related Products by Target Microtubule/Tubulin |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 620.6±55.0 °C at 760 mmHg |
| Molecular Formula | C26H38N4O |
| Molecular Weight | 422.606 |
| Flash Point | 329.1±31.5 °C |
| Exact Mass | 422.304565 |
| LogP | 5.88 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.547 |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |