Name | TR antagonist 1 |
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Description | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. |
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Related Catalog | |
Target |
IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α)[1] |
In Vitro | TR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC50=36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC50 32 nM for both TRAFα1 and TRAFβ1[1]. |
In Vivo | TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model[1]. |
References |
Molecular Formula | C25H23Br2NO4 |
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Molecular Weight | 561.26 |