(N-Me-Phe7)-Neurokinin B trifluoroacetate salt

Modify Date: 2025-08-31 16:12:51

(N-Me-Phe7)-Neurokinin B trifluoroacetate salt Structure
(N-Me-Phe7)-Neurokinin B trifluoroacetate salt structure
Common Name (N-Me-Phe7)-Neurokinin B trifluoroacetate salt
CAS Number 110880-53-0 Molecular Weight 1272.494
Density 1.3±0.1 g/cm3 Boiling Point 1654.9±65.0 °C at 760 mmHg
Molecular Formula C60H81N13O14S2 Melting Point N/A
MSDS N/A Flash Point 954.6±34.3 °C

 Use of (N-Me-Phe7)-Neurokinin B trifluoroacetate salt


[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].

 Names

Name L-α-Aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
Synonym More Synonyms

  Biological Activity

Description [MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].
Related Catalog
Target

NK3:3 nM (IC50)

References

[1]. Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21(8):2413-2417.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1654.9±65.0 °C at 760 mmHg
Molecular Formula C60H81N13O14S2
Molecular Weight 1272.494
Flash Point 954.6±34.3 °C
Exact Mass 1271.546753
LogP 4.25
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.604

 Synonyms

L-α-Aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
L-Methioninamide, L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-
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