(N-Me-Phe7)-Neurokinin B trifluoroacetate salt

Names

[ Name ]:
(N-Me-Phe7)-Neurokinin B trifluoroacetate salt

[Synonym ]:
L-α-Aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
L-Methioninamide, L-α-aspartyl-L-methionyl-L-histidyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-

Biological Activity

[Description]:

[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC50 value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R)[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK3:3 nM (IC50)

[References]

[1]. Misu R, et, al. Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists. Bioorg Med Chem. 2013 Apr 15;21(8):2413-2417.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1654.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆₀H₈₁N₁₃O₁₄S₂

[ Molecular Weight ]:
1272.494

[ Flash Point ]:
954.6±34.3 °C

[ Exact Mass ]:
1271.546753

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.604

Related Compounds

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