GRL 0617

Modify Date: 2024-01-06 11:07:51

GRL 0617 Structure
GRL 0617 structure
Common Name GRL 0617
CAS Number 1093070-16-6 Molecular Weight 304.38600
Density N/A Boiling Point N/A
Molecular Formula C20H20N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GRL 0617


GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].

 Names

Name 5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
Synonym More Synonyms

 GRL 0617 Biological Activity

Description GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].
Related Catalog
Target

IC50: 0.6 μM (SARS-CoV PLpro)[1]

References

[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

 Chemical & Physical Properties

Molecular Formula C20H20N2O
Molecular Weight 304.38600
Exact Mass 304.15800
PSA 58.61000
LogP 4.85890

 Synonyms

I06-1403
5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
5-amino-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide
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