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GRL 0617

Names

[ CAS No. ]:
1093070-16-6

[ Name ]:
GRL 0617

[Synonym ]:
I06-1403
5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
5-amino-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide

Biological Activity

[Description]:

GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 0.6 μM (SARS-CoV PLpro)[1]


[References]

[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20N2O

[ Molecular Weight ]:
304.38600

[ Exact Mass ]:
304.15800

[ PSA ]:
58.61000

[ LogP ]:
4.85890

Related Compounds