Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GRL-0496
Price: Check
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GRL-0496
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1087243-14-8

1087243-14-8 structure

1087243-14-8 structure

Name: GRL-0496
Chemical Name: GRL-0496
CAS Number: 1087243-14-8
Molecular Formula: C₁₄H₉ClN₂O₂
Molecular Weight: 272.69
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2021-09-11 19:50:48
Modify Date: 2025-08-25 14:42:14
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].

Name	GRL-0496

Description	GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 30 nM (SARS-CoV 3CLpro)[1]
In Vitro	GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].
References	[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.

Molecular Formula	C₁₄H₉ClN₂O₂
Molecular Weight	272.69

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