Guanidine-d5 hydrochloride

Modify Date: 2024-01-16 17:32:07

Guanidine-d5 hydrochloride structure	Common Name	Guanidine-d5 hydrochloride
	CAS Number	108694-93-5	Molecular Weight	101.56800
	Density	1.69g/cm3	Boiling Point	132.9ºC at 760 mmHg
	Molecular Formula	CClD₆N₃	Melting Point	185-189ºC(lit.)
	MSDS	Chinese USA	Flash Point	34.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Guanidine-d5 hydrochloride

Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3].

Name	Guanidine-d5 deuteriochloride
Synonym	More Synonyms

Description	Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4. [3]. G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul43(1):7-10. [4]. Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8450(4):1339-44. [5]. E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec2(6):339-46.

Description

Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.

[3]. G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul43(1):7-10.

[4]. Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8450(4):1339-44.

[5]. E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec2(6):339-46.

Density	1.69g/cm3
Boiling Point	132.9ºC at 760 mmHg
Melting Point	185-189ºC(lit.)
Molecular Formula	CClD₆N₃
Molecular Weight	101.56800
Flash Point	34.2ºC
Exact Mass	101.06300
PSA	75.89000
LogP	1.14090
Vapour Pressure	8.67mmHg at 25°C
Index of Refraction	1.595

Guanidine-d5 hydrochloride MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

MFCD00144417

Guanidine-d5 Hydrochloride-d

Guanidinium-Kation

guanidin*2HCl

guanidine dihydrochloride

Guanidine-d5 hydrochloride

Use of Guanidine-d5 hydrochloride

Names

Guanidine-d5 hydrochloride Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms