Guanidine-d5 hydrochloride

Names

[ Name ]:
Guanidine-d5 hydrochloride

[Synonym ]:
MFCD00144417
Guanidine-d5 Hydrochloride-d
Guanidinium-Kation
guanidin*2HCl
guanidine dihydrochloride

Biological Activity

[Description]:

Guanidine-d5 (hydrochloride) is the deuterium labeled Guanidine hydrochloride[1]. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[2][3].

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.

[3]. G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul43(1):7-10.

[4]. Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8450(4):1339-44.

[5]. E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec2(6):339-46.

Chemical & Physical Properties

[ Density]:
1.69g/cm3

[ Boiling Point ]:
132.9ºC at 760 mmHg

[ Melting Point ]:
185-189ºC(lit.)

[ Molecular Formula ]:
CClD₆N₃

[ Molecular Weight ]:
101.56800

[ Flash Point ]:
34.2ºC

[ Exact Mass ]:
101.06300

[ PSA ]:
75.89000

[ LogP ]:
1.14090

[ Vapour Pressure ]:
8.67mmHg at 25°C

[ Index of Refraction ]:
1.595

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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