Guanidine hydrochloride
Names
[ CAS No. ]:
50-01-1
[ Name ]:
Guanidine hydrochloride
[Synonym ]:
ZYZUM &&HCl
Guanidine hydrochloride (1:1)
guanidinium chloride
Guanidine, hydrochloride (1:1)
Guanidine monohydrochloride
Amino(imino)methanaminium chloride
GdmCl
Guanidine (hydrochloride)
guanidine chlorhydrate
hydrochloric acid guanidine
Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride
Guanidine Hydrochlor
Guanidine chloride
Aminoformamidine hydrochloride
GUANIDIUM CHLORIDE
GUHY
Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride
1-methylguanidine hydrochloride
Aminomethanamidine hydrochlorid
MFCD00013026
AMINOFORMAMIDINE HCL
Guanidinehydrochloride
Guanidine, monohydrochloride
usafek-749
EINECS 200-002-3
Guanidinhydrochlorid
Guanidine Hydrochloride
Guanidine HCl
guanidinium hydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.18 g/mL at 25 °C(lit.)
[ Boiling Point ]:
132.9ºC at 760 mmHg
[ Melting Point ]:
180-185 °C(lit.)
[ Molecular Formula ]:
CH6ClN3
[ Molecular Weight ]:
95.531
[ Exact Mass ]:
95.025024
[ PSA ]:
75.89000
[ LogP ]:
1.14090
[ Index of Refraction ]:
n20/D 1.465
[ Storage condition ]:
Store at RT.
[ Stability ]:
Stable. Hygroscopic. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
2280 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MF4300000
- CHEMICAL NAME :
- Guanidine, monohydrochloride
- CAS REGISTRY NUMBER :
- 50-01-1
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C-H5-N3.Cl-H
- MOLECULAR WEIGHT :
- 95.55
- WISWESSER LINE NOTATION :
- ZYZUM &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 475 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 404 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 571 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraarterial
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 4 mmol/L
- REFERENCE :
- BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,531,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3755 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 22 No. of Employees: 2097 (estimated) No. of Female Employees: 589 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H332-H315-H319
[ Precautionary Statements ]:
P261-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/38
[ Safety Phrases ]:
S26-S36-S22
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
MF4300000
[ HS Code ]:
2925290090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925290090
[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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