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50-01-1

50-01-1 structure
50-01-1 structure
  • Name: Guanidine hydrochloride
  • Chemical Name: Guanidine hydrochloride
  • CAS Number: 50-01-1
  • Molecular Formula: CH6ClN3
  • Molecular Weight: 95.531
  • Catalog: Chemical reagent Organic reagent Barium salt
  • Create Date: 2018-06-19 19:18:07
  • Modify Date: 2025-08-20 17:49:34
  • Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].
Name Guanidine hydrochloride
Synonyms ZYZUM &&HCl
Guanidine hydrochloride (1:1)
guanidinium chloride
Guanidine, hydrochloride (1:1)
Guanidine monohydrochloride
Amino(imino)methanaminium chloride
GdmCl
Guanidine (hydrochloride)
guanidine chlorhydrate
hydrochloric acid guanidine
Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride
Guanidine Hydrochlor
Guanidine chloride
Aminoformamidine hydrochloride
GUANIDIUM CHLORIDE
GUHY
Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride
1-methylguanidine hydrochloride
Aminomethanamidine hydrochlorid
MFCD00013026
AMINOFORMAMIDINE HCL
Guanidinehydrochloride
Guanidine, monohydrochloride
usafek-749
EINECS 200-002-3
Guanidinhydrochlorid
Guanidine Hydrochloride
Guanidine HCl
guanidinium hydrochloride
Description Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].
Related Catalog
References

[1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4.

[2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10.
Density 1.18 g/mL at 25 °C(lit.)
Boiling Point 132.9ºC at 760 mmHg
Melting Point 180-185 °C(lit.)
Molecular Formula CH6ClN3
Molecular Weight 95.531
Exact Mass 95.025024
PSA 75.89000
LogP 1.14090
Index of Refraction n20/D 1.465
Storage condition Store at RT.
Stability Stable. Hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility 2280 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF4300000
CHEMICAL NAME :
Guanidine, monohydrochloride
CAS REGISTRY NUMBER :
50-01-1
LAST UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C-H5-N3.Cl-H
MOLECULAR WEIGHT :
95.55
WISWESSER LINE NOTATION :
ZYZUM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
475 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
404 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
571 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Behavioral - irritability
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraarterial
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
4 mmol/L
REFERENCE :
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,531,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3755 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 22 No. of Employees: 2097 (estimated) No. of Female Employees: 589 (estimated)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H332-H315-H319
Precautionary Statements P261-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/38
Safety Phrases S26-S36-S22
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS MF4300000
HS Code 2925290090
57-13-6 structure

57-13-6

~%

50-01-1 structure

50-01-1

Literature: Sander Patent: DE527237 , 1928 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 358
56-23-5 structure

56-23-5

7664-41-7 structure

7664-41-7

~%

50-01-1 structure

50-01-1

Literature: Staehler, A. Ber. Dtsch. Chem. Ges., 1914 , vol. 47, p. 903 - 913
7446-70-0 structure

7446-70-0

7664-41-7 structure

7664-41-7

57-13-6 structure

57-13-6

~%

50-01-1 structure

50-01-1

Literature: Gmelin Handbook: C: MVol.D1, 49.1.2, page 466 - 467 Full Text Show Details Sander, F. Patent: DE527237 , 1931 ;
127099-85-8 structure

127099-85-8

~%

645-93-2 structure

645-93-2

50-01-1 structure

50-01-1

56-03-1 structure

56-03-1

Literature: Rathke Chemische Berichte, 1885 , vol. 18, p. 3106 Chemische Berichte, 1887 , vol. 20, p. 1059
56-23-5 structure

56-23-5

7664-41-7 structure

7664-41-7

7553-56-2 structure

7553-56-2

~%

74-90-8 structure

74-90-8

Detail
Literature: Staehler Chemische Berichte, 1914 , vol. 47, p. 912
7664-41-7 structure

7664-41-7

31407-74-6 structure

31407-74-6

~%

50-01-1 structure

50-01-1

Literature: Knorr Chemische Berichte, 1917 , vol. 50, p. 234
1674-62-0 structure

1674-62-0

~%

420-04-2 structure

420-04-2

471-29-4 structure

471-29-4

50-01-1 structure

50-01-1

Detail
Literature: Sugino; Yamashida Nippon Kagaku Kaishi, 1944 , vol. 65, p. 271,279 Chem.Abstr., 1947 , p. 3763
HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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