Guanidine hydrochloride

Modify Date: 2024-01-02 18:22:29

Guanidine hydrochloride structure	Common Name	Guanidine hydrochloride
	CAS Number	50-01-1	Molecular Weight	95.531
	Density	1.18 g/mL at 25 °C(lit.)	Boiling Point	132.9ºC at 760 mmHg
	Molecular Formula	CH₆ClN₃	Melting Point	180-185 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Guanidine hydrochloride

Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].

Name	Guanidine hydrochloride
Synonym	More Synonyms

Description	Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4. [2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4.

[2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10.

Density	1.18 g/mL at 25 °C(lit.)
Boiling Point	132.9ºC at 760 mmHg
Melting Point	180-185 °C(lit.)
Molecular Formula	CH₆ClN₃
Molecular Weight	95.531
Exact Mass	95.025024
PSA	75.89000
LogP	1.14090
Index of Refraction	n20/D 1.465
Storage condition	Store at RT.
Stability	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility	2280 g/L (20 ºC)

Guanidine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF4300000

CHEMICAL NAME :: Guanidine, monohydrochloride

CAS REGISTRY NUMBER :: 50-01-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C-H5-N3.Cl-H

MOLECULAR WEIGHT :: 95.55

WISWESSER LINE NOTATION :: ZYZUM &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 404 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 571 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle contraction or spasticity Behavioral - irritability

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 4 mmol/L

REFERENCE :: BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 53,531,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3755 No. of Facilities: 115 (estimated) No. of Industries: 2 No. of Occupations: 22 No. of Employees: 2097 (estimated) No. of Female Employees: 589 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H332-H315-H319
Precautionary Statements	P261-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/38
Safety Phrases	S26-S36-S22
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	MF4300000
HS Code	2925290090

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Precursor 7
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HS Code	2925290090
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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ZYZUM &&HCl

Guanidine hydrochloride (1:1)

guanidinium chloride

Guanidine, hydrochloride (1:1)

Guanidine monohydrochloride

Amino(imino)methanaminium chloride

GdmCl

Guanidine (hydrochloride)

guanidine chlorhydrate

hydrochloric acid guanidine

Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride

Guanidine Hydrochlor

Guanidine chloride

Aminoformamidine hydrochloride

GUANIDIUM CHLORIDE

GUHY

Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride

1-methylguanidine hydrochloride

Aminomethanamidine hydrochlorid

MFCD00013026

AMINOFORMAMIDINE HCL

Guanidinehydrochloride

Guanidine, monohydrochloride

usafek-749

EINECS 200-002-3

Guanidinhydrochlorid

Guanidine Hydrochloride

Guanidine HCl

guanidinium hydrochloride

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Guanidine hydrochloride
Price: ￥1638.0/5kg ￥48.0/100g ￥198.0/500g ￥Inquiry/100kg
Purity: 98.0%
Stocking Period: Inquiry
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Guanidine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Guanidine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Guanidine hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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