Dimethyl malonate structure
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Common Name | Dimethyl malonate | ||
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CAS Number | 108-59-8 | Molecular Weight | 132.115 | |
Density | 1.1±0.1 g/cm3 | Boiling Point | 177.1±8.0 °C at 760 mmHg | |
Molecular Formula | C5H8O4 | Melting Point | −62 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 90.0±0.0 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Dimethyl malonateDimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. |
Name | Dimethyl malonate |
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Synonym | More Synonyms |
Description | Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1]. |
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Related Catalog | |
In Vivo | Dimethyl malonate (6 mg/kg/min; intravenous infusion; 51 min) promotes return of spontaneous circulation (ROSC) and neurological performance in rats after cardiac arrest[1]. Animal Model: Sprague-Dawley male rats, cardiac arrest model[1] Dosage: 6 mg/kg/min Administration: Intravenous infusion, 51 min Result: Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion. |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 177.1±8.0 °C at 760 mmHg |
Melting Point | −62 °C(lit.) |
Molecular Formula | C5H8O4 |
Molecular Weight | 132.115 |
Flash Point | 90.0±0.0 °C |
Exact Mass | 132.042252 |
PSA | 52.60000 |
LogP | -0.36 |
Vapour density | >1 (vs air) |
Vapour Pressure | 1.1±0.3 mmHg at 25°C |
Index of Refraction | 1.402 |
Stability | Stable. Incompatible with strong oxidizing agents. Flammable. |
Water Solubility | negligible |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
WGK Germany | 1 |
RTECS | OO0950000 |
HS Code | 29171910 |
Precursor 10 | |
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DownStream 10 | |
HS Code | 2917190090 |
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Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.
J. Mol. Cell. Cardiol. 88 , 73-81, (2015) Succinylation refers to modification of lysine residues with succinyl groups donated by succinyl-CoA. Sirtuin5 (Sirt5) is a mitochondrial NAD(+)-dependent deacylase that catalyzes the removal of succi... |
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Enantioselective modular synthesis of 2,4-disubstituted cyclopentenones by iridium-catalyzed allylic alkylation.
Angew. Chem. Int. Ed. Engl. 45(15) , 2466-9, (2006)
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A rapid method for the synthesis of methylmalonyl-coenzyme A and other CoA-esters.
Anal. Biochem. 214(1) , 318-20, (1993) A rapid and high-yield synthesis of methylmalonyl coenzyme A is reported. The two-step procedure involves preparation of the thiophenyl ester of methylmalonic acid using dicyclohexylcarbodiimide as a ... |
dimethyl propanedioate |
Propanedioic acid, dimethyl ester |
Dimethyl malonate |
MFCD00008460 |
Malonic acid dimethyl ester |
methyl malonate |
EINECS 203-597-8 |
Malonic acid, dimethyl ester |