108-59-8

108-59-8 structure

Name: Dimethyl malonate
Chemical Name: Dimethyl malonate
CAS Number: 108-59-8
Molecular Formula: C₅H₈O₄
Molecular Weight: 132.115
Catalog: Chemical reagent Organic reagent Ester Methyl ester compound
Create Date: 2018-03-30 08:00:00
Modify Date: 2025-08-20 18:30:51
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].

Name	Dimethyl malonate
Synonyms	dimethyl propanedioate Propanedioic acid, dimethyl ester Dimethyl malonate MFCD00008460 Malonic acid dimethyl ester methyl malonate EINECS 203-597-8 Malonic acid, dimethyl ester

Description	Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Neurological Disease
In Vivo	Dimethyl malonate (6 mg/kg/min; intravenous infusion; 51 min) promotes return of spontaneous circulation (ROSC) and neurological performance in rats after cardiac arrest[1]. Animal Model: Sprague-Dawley male rats, cardiac arrest model[1] Dosage: 6 mg/kg/min Administration: Intravenous infusion, 51 min Result: Improved ROSC after CA. Prevented the decline in neurological function and inhibited the apoptosis of hippocampal neurons at day 3 after CPR. Inhibited caspase-3 cleavage and increased HIF-1α expression at day 3 after CPR. Decreased the level of oxidative stress at day 3 after CPR. Inhibited excessive hyperpolarization of MMP and restrained the leakage of cytochrome C after 45 min reperfusion.
References	[1]. Xu J, et al. Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest. Neuroscience. 2018 Nov 21;393:24-32.

Density	1.1±0.1 g/cm3
Boiling Point	177.1±8.0 °C at 760 mmHg
Melting Point	−62 °C(lit.)
Molecular Formula	C₅H₈O₄
Molecular Weight	132.115
Flash Point	90.0±0.0 °C
Exact Mass	132.042252
PSA	52.60000
LogP	-0.36
Vapour density	>1 (vs air)
Vapour Pressure	1.1±0.3 mmHg at 25°C
Index of Refraction	1.402
Stability	Stable. Incompatible with strong oxidizing agents. Flammable.
Water Solubility	negligible

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979 ** ACUTE TOXICITY DATA **

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,363,1979

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	1
RTECS	OO0950000
HS Code	29171910

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%