P2X7-IN-2

Modify Date: 2024-01-02 13:54:25

P2X7-IN-2 structure	Common Name	P2X7-IN-2
	CAS Number	1058709-63-9	Molecular Weight	435.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₁F₄N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of P2X7-IN-2

P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].

Name	P2X7-IN-2

Description	P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Target	IC50: 0.01 nM (human whole blood IL-Iβ release)[1]
In Vitro	P2X7-IN-2 (0-1 μM;30 min) inhibits human whole blood IL-Iβ release with an IC50 value of 0.01 nM[1].
References	[1]. Kelly, Michael G, et al. Preparation of isoquinolonecarboxamides as P2X7 purinoceptor modulators and uses thereof. WO2008112205 A1. 2008.

Molecular Formula	C₂₂H₂₁F₄N₃O₂
Molecular Weight	435.41
InChIKey	RKIHNKBYTUYHDG-CYBMUJFWSA-N
SMILES	Cc1ccc2c(=O)n(C(C)CN)ccc2c1NC(=O)Cc1ccc(C(F)(F)F)c(F)c1

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