P2X7-IN-2

Names

[ CAS No. ]:
1058709-63-9

[ Name ]:
P2X7-IN-2

Biological Activity

[Description]:

P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

IC50: 0.01 nM (human whole blood IL-Iβ release)[1]


[In Vitro]

P2X7-IN-2 (0-1 μM;30 min) inhibits human whole blood IL-Iβ release with an IC50 value of 0.01 nM[1].

[References]

[1]. Kelly, Michael G, et al. Preparation of isoquinolonecarboxamides as P2X7 purinoceptor modulators and uses thereof. WO2008112205 A1. 2008.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H21F4N3O2

[ Molecular Weight ]:
435.41

Related Compounds