SU 5614
Modify Date: 2025-08-23 16:57:39
SU 5614 structure
|
Common Name | SU 5614 | ||
|---|---|---|---|---|
| CAS Number | 1055412-47-9 | Molecular Weight | 272.73000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13ClN2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of SU 5614(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. |
| Name | 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C15H13ClN2O |
|---|---|
| Molecular Weight | 272.73000 |
| Exact Mass | 272.07200 |
| PSA | 48.38000 |
| LogP | 3.86270 |
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia.
Oncotarget 6 , 38804-15, (2015) Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemi... |
|
|
VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.
Biol. Open 4 , 1063-76, (2015) Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 s... |
| 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone |
| 1H-Indole-2-carboxylic acid,5-chloro-3-[(3,5-dimethylphenyl)sulfonyl] |
| 5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid |
| 5-chloro-3-(3,5-dimethyl-1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one |
| 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid |
| 3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid |
| SU 5614 |
| SU5614 |