SU 5614

Names

[ Name ]:
SU 5614

[Synonym ]:
5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone
1H-Indole-2-carboxylic acid,5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]
5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid
5-chloro-3-(3,5-dimethyl-1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one
5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid
3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid
SU 5614
SU5614

Biological Activity

[Description]:

(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[References]

[1]. Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101(4):1494-504.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₃ClN₂O

[ Molecular Weight ]:
272.73000

[ Exact Mass ]:
272.07200

[ PSA ]:
48.38000

[ LogP ]:
3.86270

Safety Information

[ Hazard Statements ]:
H413

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia.

Oncotarget 6 , 38804-15, (2015)

Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemi...

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.

Biol. Open 4 , 1063-76, (2015)

Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 s...

Related Compounds

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