SU 5614
SU 5614 structure
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Common Name | SU 5614 | ||
|---|---|---|---|---|
| CAS Number | 1055412-47-9 | Molecular Weight | 272.73000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13ClN2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of SU 5614(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C15H13ClN2O |
|---|---|
| Molecular Weight | 272.73000 |
| Exact Mass | 272.07200 |
| PSA | 48.38000 |
| LogP | 3.86270 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Statements | H413 |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia.
Oncotarget 6 , 38804-15, (2015) Internal tandem duplications within the juxtamembrane region of the FMS-like tyrosine kinase receptor FLT3 (FLT3-ITD) represents one of the most common mutations in patients with acute myeloid leukemi... |
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VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.
Biol. Open 4 , 1063-76, (2015) Neuropilin-1 (NRP1) has been identified as a VEGF-A receptor. DJM-1, a human skin cancer cell line, expresses endogenous VEGF-A and NRP1. In the present study, the RNA interference of VEGF-A or NRP1 s... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone |
| 1H-Indole-2-carboxylic acid,5-chloro-3-[(3,5-dimethylphenyl)sulfonyl] |
| 5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid |
| 5-chloro-3-(3,5-dimethyl-1H-pyrrol-2-yl-methylene)-1,3-dihydro-indol-2-one |
| 5-chloro-3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid |
| 3-[(3,5-dimethylphenyl)sulfonyl]-1H-indole-2-carboxylic acid |
| SU 5614 |
| SU5614 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: Polar surface area (PSA) of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is 48.38000. |
| Q: What is the LogP of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: LogP of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is 3.86270. |
| Q: What is the molecular formula of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: Molecular formula of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is C15H13ClN2O. |
| Q: What are the uses of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: Main uses of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one: (Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1]. |
| Q: What is the CAS number of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: CAS number of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is 1055412-47-9. |
| Q: What is the molecular weight of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: Molecular weight of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is 272.73000. |
| Q: What is the English name of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one? |
| A: The English name of 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one is 5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2 H-indol-2-one. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |